The origin of matrix metalloproteinases and their familial relationships

FEBS Lett. 1991 Sep 2;289(1):4-7. doi: 10.1016/0014-5793(91)80895-a.


New computer comparisons of the sequences of mammalian matrix metalloproteinases have established for the first time strong links with bacterial metalloproteinases. We also propose that there are five groups in the family of matrix metalloproteinases, although only three are as yet well-characterized as proteins, and discuss their origin and relationships with other zinc containing proteases.

MeSH terms

  • Amino Acid Sequence
  • Bacteria / enzymology
  • Extracellular Matrix / enzymology*
  • Matrix Metalloproteinase 3
  • Metalloendopeptidases / genetics*
  • Molecular Sequence Data
  • Phylogeny
  • Sequence Alignment
  • Sequence Homology, Nucleic Acid
  • Software


  • Metalloendopeptidases
  • Matrix Metalloproteinase 3