Smooth-muscle myosin mutations in hereditary non-polyposis colorectal cancer syndrome

Br J Cancer. 2008 Nov 18;99(10):1726-8. doi: 10.1038/sj.bjc.6604737. Epub 2008 Oct 21.


We examined adenomas and cancers from hereditary non-polyposis colorectal cancer (HNPCC) syndrome patients for the presence of frameshift mutations in the smooth-muscle myosin gene, MYH11. Our results show that mutations in MYH11 occur more frequently in cancers than adenomas (P=0.008) and are dependent on microsatellite instability (MSI+).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoma / genetics
  • Colorectal Neoplasms, Hereditary Nonpolyposis / genetics*
  • Frameshift Mutation
  • Humans
  • Microsatellite Instability
  • Myosin Heavy Chains / genetics*
  • Smooth Muscle Myosins / genetics*


  • MYH11 protein, human
  • Smooth Muscle Myosins
  • Myosin Heavy Chains