A detailed methodology of partial hepatectomy in the mouse

Lab Anim (NY). 2008 Nov;37(11):529-32. doi: 10.1038/laban1108-529.


The technique of partial hepatectomy is widely used to model liver regeneration and cell cycle dynamics in vivo. Because murine gene expression can be manipulated relatively easily, partial hepatectomy in mice is a useful tool for exploring the contributions of different genes to such hepatic processes. The authors present a straightforward method of partial hepatectomy in the mouse.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Laboratory
  • Disease Models, Animal
  • Hepatectomy / methods
  • Hepatectomy / veterinary*
  • Liver / surgery*
  • Mice / surgery*