Tumor growth of suspected meningiomas in clinically healthy 80-year-olds: a follow up five years later

Zentralbl Neurochir. 2008 Nov;69(4):182-6. doi: 10.1055/s-2008-1080940. Epub 2008 Oct 23.


Background: The incidence of clinically silent meningiomas in 75-year-old individuals was determined five years ago in the Vienna Transdanube Ageing Study (VITA). At the time a watch-and-wait approach was recommended in cases of incidentally discovered meningiomas.

Methods: 420 out of the initial cohort of 532 test persons underwent control investigations after 2.5 and 5 years. Six of the nine known tumors were measured again and the patients underwent clinical, neurological and psychological tests. Changes in tumor size were determined and all new tumors seen on MRI investigation were carefully reviewed.

Results: Tumor growth was minimal in all six cases that were followed over the entire period. Two of the original meningioma patients had died and one patient had undergone tumor resection.

Conclusions: The watch-and-wait approach recommended after the VITA study was confirmed by the present investigation. Tumor growth was slow in all cases; no clinical symptoms have been registered thus far. The intervals between control investigations may even be prolonged depending on the location of the tumor. In this age group the operation appears to pose a greater risk than the presence of an asymptomatic tumor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged, 80 and over / physiology*
  • Cohort Studies
  • Contrast Media
  • Disease Progression
  • Follow-Up Studies
  • Gadolinium
  • Humans
  • Insulin-Like Growth Factor I / metabolism
  • Magnetic Resonance Imaging
  • Meningioma / pathology*
  • Meningioma / surgery
  • Neurosurgical Procedures


  • Contrast Media
  • Insulin-Like Growth Factor I
  • Gadolinium