Effect of ripe fruit pulp extract of Cucurbita pepo Linn. in aspirin induced gastric and duodenal ulcer in rats

Indian J Exp Biol. 2008 Sep;46(9):639-45.

Abstract

A significant decrease in alkaline phosphatase (AP) activity and mucosal thickness and increase in ulcer index (UI) was observed in aspirin treated stomach and duodenum of albino rats. However, pretreatment with C. pepo fruit pulp extract for 14 consecutive days showed increase in AP activity and mucosal thickness along with decrease in UI, suggesting gastroduodenal protective and anti-ulcerogenic properties of C. pepo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Ulcer Agents / therapeutic use
  • Aspirin / pharmacology*
  • Cucurbita / chemistry*
  • Cucurbita / growth & development
  • Duodenal Ulcer / chemically induced
  • Duodenal Ulcer / drug therapy*
  • Duodenal Ulcer / pathology
  • Female
  • Fruit / chemistry*
  • Fruit / growth & development
  • Male
  • Plant Extracts / chemistry*
  • Plant Extracts / therapeutic use*
  • Rats
  • Stomach Ulcer / chemically induced
  • Stomach Ulcer / drug therapy*
  • Stomach Ulcer / pathology

Substances

  • Anti-Ulcer Agents
  • Plant Extracts
  • Aspirin