FIZZ1 plays a crucial role in early stage airway remodeling of OVA-induced asthma

J Asthma. 2008 Oct;45(8):648-53. doi: 10.1080/02770900802126941.


The aim of this study was to elucidate the role of Found in Inflammatory Zone 1 (FIZZ1, also known as RELM-alpha or resistin-like molecule-alpha) in airway remodeling in asthma. We used a rat model of ovalbumin (OVA) sensitization and challenge to induce lung inflammation and remodeling. Expression of alpha -SMA in the lungs of OVA-treated rats was significantly elevated in the peribronchial regions compared with control saline-treated animals. Expression of FIZZ1 mRNA in alveolar epithelial type II cells (AECII) isolated from OVA-treated animals was higher than in control animals. Forced expression of recombinant FIZZ1 in rat-1 lung fibroblast cell line enhanced production of collagen type I and alpha -SMA compared with control transfected cells. These results suggest that FIZZ1 can induce fibroblasts to express markers of myofibroblast differentiation such as alpha -SMA and collagen type I, which are characteristic of early stages of airway remodeling seen in asthma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actins / biosynthesis
  • Actins / genetics
  • Animals
  • Asthma / genetics
  • Asthma / metabolism
  • Asthma / pathology*
  • Cell Differentiation / physiology
  • Cell Line
  • Collagen Type I / biosynthesis
  • Fibroblasts / pathology
  • Immunohistochemistry
  • Lung / pathology*
  • Nerve Growth Factor / biosynthesis*
  • Nerve Growth Factor / genetics
  • Ovalbumin / pharmacology
  • RNA, Messenger / biosynthesis
  • RNA, Messenger / genetics
  • Rats
  • Rats, Wistar
  • Reverse Transcriptase Polymerase Chain Reaction
  • Specific Pathogen-Free Organisms
  • Transfection


  • Actins
  • Collagen Type I
  • RNA, Messenger
  • Retnla protein, rat
  • Ovalbumin
  • Nerve Growth Factor