Gammadelta T-cells: potential regulators of the post-burn inflammatory response

Burns. 2009 May;35(3):318-26. doi: 10.1016/j.burns.2008.08.002. Epub 2008 Oct 31.


Severe burn induces an immunopathological response that contributes to the development of a systemic inflammatory response (SIRS) and subsequent multiple organ failure. While, multiple immune cells type (T-cells, macrophages, neutrophils) are involved in this response, recent evidence suggests that a unique T-cell subset, gammadelta T-cells are central in the response to injury. While gammadelta T-cells represent only a small percentage of the total T-cell population, they display specific functional characteristics that uniquely position them in the immune/inflammatory axis to influence a number of important aspects of the body's response to burn. This review will focus on the potential regulator role of gammadelta T-cells in immunopathological response following burn and thereby their potential as therapeutic targets for affecting inflammation and healing.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biomarkers / metabolism
  • Burns / immunology*
  • Burns / therapy
  • Humans
  • Immunity, Cellular
  • Immunotherapy / methods
  • Inflammation / immunology
  • Lymphocyte Activation / immunology
  • Mice
  • Skin / immunology
  • T-Lymphocyte Subsets / physiology*
  • T-Lymphocyte Subsets / transplantation
  • T-Lymphocytes / immunology
  • Wound Healing / immunology*


  • Biomarkers