Structural basis for exon recognition by a group II intron

Nat Struct Mol Biol. 2008 Nov;15(11):1221-2. doi: 10.1038/nsmb.1509. Epub 2008 Oct 26.


Free group II introns are infectious retroelements that can bind and insert themselves into RNA and DNA molecules via reverse splicing. Here we report the 3.4-A crystal structure of a complex between an oligonucleotide target substrate and a group IIC intron, as well as the refined free intron structure. The structure of the complex reveals the conformation of motifs involved in exon recognition by group II introns.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Crystallography, X-Ray
  • Exons*
  • Introns*
  • Models, Molecular
  • Molecular Sequence Data
  • Nucleic Acid Conformation*

Associated data

  • PDB/3EOG
  • PDB/3EOH