The coagulant response in sepsis

Clin Chest Med. 2008 Dec;29(4):627-42, viii. doi: 10.1016/j.ccm.2008.06.006.


Sepsis is often associated with systemic intravascular activation of coagulation, potentially leading to widespread microvascular deposits of fibrin, and thereby contributing to multiple organ dysfunction. A complex interaction exists between activation of inflammatory systems and the initiating and regulating pathways of coagulation. A diagnosis of sepsis-associated disseminated intravascular coagulation can be made by a combination of routinely available laboratory tests, for which simple diagnostic algorithms have become available. Strategies to inhibit coagulation activation may theoretically be justified and are being evaluated in clinical studies.

Publication types

  • Review

MeSH terms

  • Anticoagulants / therapeutic use
  • Antithrombin III / physiology
  • Disseminated Intravascular Coagulation / blood*
  • Disseminated Intravascular Coagulation / diagnosis
  • Disseminated Intravascular Coagulation / therapy
  • Glycocalyx / physiology
  • Humans
  • Multiple Organ Failure / blood
  • Multiple Organ Failure / diagnosis
  • Multiple Organ Failure / therapy
  • Plasma
  • Platelet Transfusion
  • Protein C / physiology
  • Sepsis / blood*
  • Sepsis / diagnosis
  • Sepsis / therapy
  • Thromboplastin / physiology


  • Anticoagulants
  • Protein C
  • Antithrombin III
  • Thromboplastin