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, 16 (23), 10034-42

Design, Synthesis and Preliminary Pharmacological Evaluation of New Analogues of DM232 (Unifiram) and DM235 (Sunifiram) as Cognition Modulators

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Design, Synthesis and Preliminary Pharmacological Evaluation of New Analogues of DM232 (Unifiram) and DM235 (Sunifiram) as Cognition Modulators

Elisabetta Martini et al. Bioorg Med Chem.

Abstract

A series of amides, structurally related to DM232 (unifiram) and DM235 (sunifiram), characterized by a 1,2,3,4-tetrahydropyrazino[2,1-a]isoindol-6(2H)-one, 1,4-diamino-cyclohexane or 1,4-diaminobenzene ring, have been synthesized and tested for cognition-enhancing activity in the mouse passive-avoidance test. Some of the compounds display good antiamnesic and procognitive activity, with higher potency than piracetam, while some cyclohexane derivatives are endowed with amnesia inducing properties.

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