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. 2011;2011:253958.
doi: 10.1093/ecam/nen063. Epub 2011 Feb 14.

Aqueous Extract of Black Maca (Lepidium Meyenii) on Memory Impairment Induced by Ovariectomy in Mice

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Aqueous Extract of Black Maca (Lepidium Meyenii) on Memory Impairment Induced by Ovariectomy in Mice

Julio Rubio et al. Evid Based Complement Alternat Med. .
Free PMC article


The present study aims to test two different doses of aqueous extract of black maca on learning and memory in ovariectomized (OVX) mice and their relation with malonalehyde (MDA), acetylcholinesterase (Ache) and monoamine oxidase (MAO) brain levels. Female mice were divided into five groups: (i) naive (control), (ii) sham, (iii) OVX mice and OVX mice treated with (iv) 0.50 g kg(-1) and (v) 2.00 g kg(-1) black maca. Mice were orally treated with distilled water or black maca during 35 days starting 7 days after surgery. Memory and learning were assessed using the water Morris maze (from day 23-27) and the step-down avoidance test (days 34 and 35). At the end of each treatment, mice were sacrificed by decapitation and brains were dissected out for MDA, Ache and MAO determinations. Black maca (0.5 and 2.0 g/kg) increased step-down latency when compared to OVX control mice. Black maca decreased MDA and Ache levels in OVX mice; whereas, no differences were observed in MAO levels. Finally, black maca improved experimental memory impairment induced by ovariectomy, due in part, by its antioxidant and Ache inhibitory activities.


Figure 1
Figure 1
Black maca on (a) swimming distance (centimeters) and (b) escape latency (s) in OVX mice during the escape acquisition test of the water Morris maze. Data are presented as mean ± SEM. *P < .05 versus OVX control.
Figure 2
Figure 2
Black#maca on (a) the time in the target quadrant (s) and (b) number of crossings in OVX mice in the Morris water maze during the spatial memory test. Data are presented as mean ± SEM. *P < .05 versus OVX control.

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