PI3K/Akt: getting it right matters

Oncogene. 2008 Oct 27;27(50):6473-88. doi: 10.1038/onc.2008.313.

Abstract

The Akt serine/threonine kinase (also called protein kinase B) has emerged as a critical signaling molecule within eukaryotic cells. Significant progress has been made in clarifying its regulation by upstream kinases and identifying downstream mechanisms that mediate its effects in cells and contribute to signaling specificity. Here, we provide an overview of present advances in the field regarding the function of Akt in physiological and pathological cell function within a more generalized framework of Akt signal transduction. An emphasis is placed on the involvement of Akt in human diseases ranging from cancer to metabolic dysfunction and mental disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Humans
  • Mental Disorders / enzymology
  • Mental Disorders / metabolism
  • Metabolic Diseases / enzymology
  • Metabolic Diseases / metabolism
  • Models, Animal
  • Models, Genetic
  • Neoplasms / enzymology
  • Neoplasms / metabolism
  • Oncogenes
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Phosphorylation
  • Proto-Oncogene Proteins c-akt / metabolism*
  • Signal Transduction

Substances

  • Phosphatidylinositol 3-Kinases
  • Proto-Oncogene Proteins c-akt