Update on apraxia

Curr Neurol Neurosci Rep. 2008 Nov;8(6):490-6. doi: 10.1007/s11910-008-0078-y.


Apraxia is classically defined as difficulty performing learned, skilled gestures. In this review, we describe the range of motor impairments classified as apraxia, focusing on ideomotor limb apraxia. We present several prominent models of praxis to explain the variety of difficulties seen in patients with apraxia. We also discuss the large-scale frontal-parietal-basal ganglia network thought to underlie praxis. In this context, we highlight the common occurrence of limb apraxia in corticobasal degeneration, a neurodegenerative condition characterized by frontal, parietal, and basal ganglia disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Apraxia, Ideomotor / pathology
  • Apraxia, Ideomotor / physiopathology*
  • Apraxias / pathology
  • Apraxias / physiopathology*
  • Behavior / physiology
  • Extremities / anatomy & histology
  • Extremities / physiology
  • Extremities / physiopathology
  • Humans
  • Models, Biological
  • Motor Activity / physiology
  • Neuropsychological Tests
  • Psychomotor Performance