Signal transduction: turning a switch into a rheostat

Curr Biol. 2008 Oct 14;18(19):R910-2. doi: 10.1016/j.cub.2008.07.082.


MAP kinase cascades are inherently switch-like, but, during yeast mating, MAPK signaling is graded. A new study suggests that the Ste5 scaffold protein is responsible for making this switch less switch-like.

Publication types

  • Comment

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism*
  • Humans
  • MAP Kinase Signaling System*
  • Saccharomyces cerevisiae / metabolism*
  • Saccharomyces cerevisiae Proteins / metabolism*


  • Adaptor Proteins, Signal Transducing
  • STE5 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins