Emergence of Qnr determinants in human Salmonella isolates in Taiwan

J Antimicrob Chemother. 2008 Dec;62(6):1269-72. doi: 10.1093/jac/dkn426. Epub 2008 Oct 27.


Objectives: The aim of this study was to determine the prevalence and characteristics of qnr-carrying Salmonella isolates from humans in southern Taiwan.

Methods: A total of 446 Salmonella isolates collected between 2003 and 2006 were screened for qnrA, qnrB and qnrS by PCR experiments. Genetic structures of qnr were determined by PCR-based methods or direct sequencing of plasmid DNA.

Results: qnrB2 and qnrS1 were detected in two serovar Enteritidis isolates and two serovar Typhimurium isolates, respectively. One qnrS1-positive isolate was found to produce the CMY-2 AmpC enzyme. qnrS1 was identified on a 10 kb plasmid, which exhibited >99% nucleotide sequence identity with plasmid TPqnrS-1a reported from the UK. qnrB2 was found in a complex sul1-type class 1 integron on a >100 kb plasmid.

Conclusions: This study demonstrated the occurrence of qnrB2 and qnrS1 in Salmonella for the first time in Taiwan and characterized their genetic structures.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / genetics*
  • DNA, Bacterial / chemistry
  • DNA, Bacterial / genetics
  • Drug Resistance, Bacterial*
  • Humans
  • Molecular Sequence Data
  • Plasmids
  • Polymerase Chain Reaction / methods
  • Quinolones / pharmacology*
  • Salmonella Infections / epidemiology
  • Salmonella Infections / microbiology*
  • Salmonella enteritidis / drug effects*
  • Salmonella enteritidis / genetics
  • Salmonella enteritidis / isolation & purification
  • Salmonella typhimurium / drug effects*
  • Salmonella typhimurium / genetics
  • Salmonella typhimurium / isolation & purification
  • Sequence Analysis, DNA
  • Sequence Homology, Nucleic Acid
  • Taiwan / epidemiology


  • Anti-Bacterial Agents
  • Bacterial Proteins
  • DNA, Bacterial
  • Quinolones

Associated data

  • GENBANK/EU715253
  • GENBANK/EU715254