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. 2009 Jan;37(Database issue):D396-403.
doi: 10.1093/nar/gkn803. Epub 2008 Oct 27.

The GOA database in 2009--an integrated Gene Ontology Annotation resource

Daniel Barrell  1 , Emily Dimmer, Rachael P Huntley, David Binns, Claire O'Donovan, Rolf Apweiler
Affiliations
Free PMC article

The GOA database in 2009--an integrated Gene Ontology Annotation resource

Daniel Barrell et al. Nucleic Acids Res. 2009 Jan.
Free PMC article

Abstract

The Gene Ontology Annotation (GOA) project at the EBI (http://www.ebi.ac.uk/goa) provides high-quality electronic and manual associations (annotations) of Gene Ontology (GO) terms to UniProt Knowledgebase (UniProtKB) entries. Annotations created by the project are collated with annotations from external databases to provide an extensive, publicly available GO annotation resource. Currently covering over 160 000 taxa, with greater than 32 million annotations, GOA remains the largest and most comprehensive open-source contributor to the GO Consortium (GOC) project. Over the last five years, the group has augmented the number and coverage of their electronic pipelines and a number of new manual annotation projects and collaborations now further enhance this resource. A range of files facilitate the download of annotations for particular species, and GO term information and associated annotations can also be viewed and downloaded from the newly developed GOA QuickGO tool (http://www.ebi.ac.uk/QuickGO), which allows users to precisely tailor their annotation set.

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Figures

Figure 1.
Figure 1.
Screenshot of the front page of the QuickGO browser (http://www.ebi.ac.uk/QuickGO).
Figure 2.
Figure 2.
QuickGO GO term information pages. QuickGO screenshots of the tabbed ‘Term Information’ and ‘Ancestor Chart’ pages for the GO term lysosome (GO:0005764).
Figure 3.
Figure 3.
QuickGO GO annotation page screenshot. QuickGO provides a range of options to tailor a GOA annotation set for downloading. The screenshot displays an annotation set which has been filtered so that only those experimentally evidenced annotations to human UniProtKB accessions are selected. This screenshot also shows the taxon filtering option, to demonstrate the ease of filtering annotation sets, as well as the statistics generated for the evidence code usage in the selected set. The bottom of this screenshot also displays the range of download options available to QuickGO.
See this image and copyright information in PMC

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