What is dorso-lateral in the subthalamic Nucleus (STN)?--a topographic and anatomical consideration on the ambiguous description of today's primary target for deep brain stimulation (DBS) surgery

Acta Neurochir (Wien). 2008 Nov;150(11):1163-5; discussion 1165. doi: 10.1007/s00701-008-0136-x. Epub 2008 Oct 29.


Introduction: The most frequently used target for DBS in advanced Parkinson Disease (PD) is the sensorimotor subthalamic nucleus (STN), anatomically referred to as dorso-lateral STN [3]. Ambiguities arise, regarding the true meaning of this description in the STN. Does "dorsal" indicate posterior or superior? At its best, this definition assigns two directions in space to a three-dimensional structure.

Objective: This paper evaluates the ambiguity and describes the sensorimotor part of the STN in stereotactic space.

MeSH terms

  • Basal Ganglia / anatomy & histology
  • Brain Mapping / methods
  • Brain Stem / anatomy & histology
  • Deep Brain Stimulation / methods*
  • Diencephalon / anatomy & histology
  • Humans
  • Magnetic Resonance Imaging / methods
  • Neuronavigation / methods
  • Parkinson Disease / physiopathology
  • Parkinson Disease / therapy*
  • Preoperative Care / methods
  • Stereotaxic Techniques / standards*
  • Substantia Nigra / anatomy & histology
  • Subthalamic Nucleus / anatomy & histology*