[Production of reconstructed two-cell rat embryos after chemical inactivation of chromosomes in MII oocytes by etoposide]

Ontogenez. 2008 Sep-Oct;39(5):340-4.
[Article in Russian]


The application of etoposide for chemical enucleation of rat oocytes was tested. The reconstruction efficiency after chemical and mechanical enucleation was comparatively analyzed. The obtained data indicate similar viability of reconstructed rat embryos irrespective of the enucleation technique.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Blastomeres / cytology
  • Blastomeres / metabolism*
  • Embryo, Mammalian / embryology*
  • Etoposide / pharmacology*
  • Female
  • Male
  • Oocytes / metabolism*
  • Rats
  • Rats, Sprague-Dawley


  • Antineoplastic Agents, Phytogenic
  • Etoposide