Quantitative treatment of substituent effects in the polarographic investigations of some potential antineoplastic 2-amino-4-aryl-5-phenylazothiazoles

W U Malik; R N Goyal; R Jain

doi:10.1016/0039-9140(78)80043-5

Quantitative treatment of substituent effects in the polarographic investigations of some potential antineoplastic 2-amino-4-aryl-5-phenylazothiazoles

Talanta. 1978 Feb;25(2):111-2. doi: 10.1016/0039-9140(78)80043-5.

Authors

W U Malik¹, R N Goyal, R Jain

Affiliation

¹ Department of Chemistry, University of Roorkee, Roorkee, India.

PMID: 18962218
DOI: 10.1016/0039-9140(78)80043-5

Abstract

Polarographic reduction of 2-amino-4-aryl-5-phenylazothiazoles takes place in a single 2-electron transfer, giving a diffusion-controlled irreversible wave in the pH range 2.0-10.0. Substituents in the 4-position of the thiazole moiety shift the half-wave potential through conjugation of the system. A correlation of E(sol;1 2 ) with the Brown and Hammett substituent constant has also been established.