Use of an ion-selective membrane electrode for the determination of the active components in intestopan

M S Ionescu; M Lazarescu; A Ionescu; G E Baiulescu

doi:10.1016/0039-9140(87)80120-0

Use of an ion-selective membrane electrode for the determination of the active components in intestopan

Talanta. 1987 Oct;34(10):887-8. doi: 10.1016/0039-9140(87)80120-0.

Authors

M S Ionescu¹, M Lazarescu, A Ionescu, G E Baiulescu

Affiliation

¹ Institute of Chemical and Pharmaceutical Research, 74351-Sos. Vitan 112, Bucharest-3, Romania.

PMID: 18964425
DOI: 10.1016/0039-9140(87)80120-0

Abstract

The conditions for the determination of broxyquinoline and brobenzoxaldine, the active components of "Intestopan", by use of ion-selective membrane electrodes are described. Broxyquinoline is determined directly through precipitation with CuSO(4), and brobenzoxaldine is first hydrolysed in alkaline solution and the product precipitated with CuSO(4). In both cases the CuSO(4) in excess is determined by potentiometric titration at pH 5.6 with EDTA, a Cu(2+)-selective electrode being used for end-point detection.