Enterostatin (Val-Pro-Asp-Pro-Arg), the activation peptide of procolipase, selectively reduces fat intake

Physiol Behav. 1991 Jun;49(6):1185-9. doi: 10.1016/0031-9384(91)90349-s.


Valine-proline-aspartate-proline-arginine (VPDPR), the amino terminal pentapeptide of pancreatic procolipase, produced a dose-dependent reduction in food intake when injected intraperitoneally into Osborne-Mendel rats that had been starved overnight. This inhibition of feeding was observed when the rats were fed a high-fat diet but not in rats fed a high-carbohydrate, low-fat diet. At higher doses of VPDPR, the inhibition of feeding was maintained for over 6 hours. An equimolar mixture of the free amino acids had no effect on food intake. In rats adapted to a three-choice macronutrient diet, VPDPR inhibited fat intake but had no effect on carbohydrate or protein intake. This selective inhibition of fat intake was observed in both overnight-fasted rats presented with food and in ad-lib-fed rats at the beginning of the dark-onset feeding period. It is suggested that this peptide may be a feedback signal to regulate the intake of dietary fat.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Body Weight / physiology
  • Circadian Rhythm / physiology
  • Colipases / physiology*
  • Dietary Fats / administration & dosage*
  • Enzyme Activation / physiology
  • Enzyme Precursors
  • Feeding Behavior / physiology
  • Food Preferences / physiology*
  • Protein Precursors / physiology*
  • Rats
  • Rats, Inbred Strains


  • Colipases
  • Dietary Fats
  • Enzyme Precursors
  • Protein Precursors
  • procolipase