Anti-tumor-promotion by principles obtained from Angelica keiskei

Planta Med. 1991 Jun;57(3):242-6. doi: 10.1055/s-2006-960082.

Abstract

Potent anti-tumor promoter activity has been found in the nonpolar extracts of the root of "Ashita-Ba", Angelica keiskei Koidz. (Umbelliferae), which is eaten as a vegetable in Japan. From this active fraction, two angular furanocoumarins, archangelicin (1) and 8(S),9(R)-9-angeloyloxy-8,9-dihydrooroselol (2), three linear furanocoumarins, psoralen (3), bergapten (4) and xanthotoxin (5), and three chalcones, 4-hydroxyderricin (6), xanthoangelol (7) and a novel chalcone named ashitaba-chalcone (8), were isolated. Among these compounds, two angular type furanocoumarins, 1 and 2, and three chalcones, 6-8, suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated 32Pi-incorporation into phospholipids of cultured cells, whereas coumarins 3-5 were less effective. In addition, chalcones 6 and 7 were proved to have anti-tumor-promoting activity in mouse skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene (DMBA) plus TPA. Since chalcones 6 and 7 showed calmodulin-interacting property, both chalcones may reveal anti-tumor-promoting activity via the modulation of calmodulin involved systems. These chalcones may be useful to develop the effective method for cancer prevention.

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic* / chemistry
  • Antineoplastic Agents, Phytogenic* / isolation & purification
  • Calmodulin / pharmacology
  • Chalcone / analogs & derivatives
  • Chalcone / chemistry
  • Chalcone / isolation & purification
  • Chalcone / pharmacology
  • Coumarins / chemistry
  • Coumarins / isolation & purification
  • Coumarins / pharmacology*
  • Drug Screening Assays, Antitumor
  • Drugs, Chinese Herbal*
  • Female
  • HeLa Cells
  • Humans
  • Magnetic Resonance Spectroscopy
  • Mice
  • Mice, Inbred ICR
  • Molecular Structure
  • Phospholipids / metabolism

Substances

  • Antineoplastic Agents, Phytogenic
  • Calmodulin
  • Coumarins
  • Drugs, Chinese Herbal
  • Phospholipids
  • 4-hydroxyderricin
  • Chalcone
  • xanthoangelol