6-Pentadecylsalicylic acid: an antithrombin component isolated from the stem of Rhus semialata var. roxburghii

Planta Med. 1991 Jun;57(3):247-9. doi: 10.1055/s-2006-960083.

Abstract

Bioassay-directed fractionation of the n-hexane extract of the stem of Rhus semialata Murr. var. roxburghii DC (Anacardiaceae) has led to the isolation of 6-pentadecylsalicylic acid. It showed antithrombin activity at 50 micrograms/ml in the amidolytic method. It also prolonged the clotting time in a dose-dependent manner in the clotting assay of thrombin-fibrinogen interaction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Anacardic Acids*
  • Animals
  • Antithrombins* / isolation & purification
  • Antithrombins* / metabolism
  • Cattle
  • Chromogenic Compounds / metabolism
  • Magnetic Resonance Spectroscopy
  • Molecular Sequence Data
  • Molecular Structure
  • Plants, Medicinal / analysis*
  • Salicylates / isolation & purification
  • Salicylates / pharmacology*

Substances

  • Anacardic Acids
  • Antithrombins
  • Chromogenic Compounds
  • Salicylates
  • anacardic acid