Abstract
Bioassay-directed fractionation of the n-hexane extract of the stem of Rhus semialata Murr. var. roxburghii DC (Anacardiaceae) has led to the isolation of 6-pentadecylsalicylic acid. It showed antithrombin activity at 50 micrograms/ml in the amidolytic method. It also prolonged the clotting time in a dose-dependent manner in the clotting assay of thrombin-fibrinogen interaction.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Anacardic Acids*
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Animals
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Antithrombins* / isolation & purification
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Antithrombins* / metabolism
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Cattle
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Chromogenic Compounds / metabolism
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Magnetic Resonance Spectroscopy
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Molecular Sequence Data
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Molecular Structure
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Plants, Medicinal / analysis*
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Salicylates / isolation & purification
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Salicylates / pharmacology*
Substances
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Anacardic Acids
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Antithrombins
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Chromogenic Compounds
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Salicylates
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anacardic acid