Determination of benorilate in pharmaceutical formulations and its metabolite in urine at carbon paste electrode modified by silver nanoparticles

Cheng Yin Wang; Xiao Ya Hu

doi:10.1016/j.talanta.2005.03.009

Determination of benorilate in pharmaceutical formulations and its metabolite in urine at carbon paste electrode modified by silver nanoparticles

Talanta. 2005 Sep 15;67(3):625-33. doi: 10.1016/j.talanta.2005.03.009. Epub 2005 Apr 18.

Authors

Cheng Yin Wang¹, Xiao Ya Hu

Affiliation

¹ Department of Chemistry and Chemical Engineering, Yangzhou University, 180 Siwangting lu, Yangzhou 225002, China.

PMID: 18970216
DOI: 10.1016/j.talanta.2005.03.009

Abstract

Benorilate was determined by the differential pulse voltammetry (DPV) using a carbon paste electrode modified by silver nanoparticles in 1.25x10(-3)moll(-1) KH(2)PO(4) and Na(2)HPO(4) buffer solution (pH=6.88, 25 degrees C) .The anodic peak potential was +0.970V (versus SCE). A good linear relationship was realized between the anodic peak currents and benorilate concentrations in the range of 1.0x10(-7) to 2.5x10(-4)moll(-1) with the detection limit of 1.0x10(-8)moll(-1). The recovery was 95.2-103.6% with the relative standard deviation of 3.6% (n=9). The pharmaceutical preparations, benorilate tablets samples and its metabolite (salicylic acid) in urine were determined with the desirable results.