Aging: ROS or TOR

Cell Cycle. 2008 Nov 1;7(21):3344-54. doi: 10.4161/cc.7.21.6965. Epub 2008 Nov 11.


It is widely believed that aging is caused by the accumulation of random molecular damage due to reactive oxygen species (ROS). Here I discuss evidence for and against the ROS theory. Remarkably, even supporting evidence has an alternative explanation, consistent with the model that aging is driven by the TOR (target of rapamycin) signaling pathway.

Publication types

  • Review

MeSH terms

  • Aging / metabolism*
  • Animals
  • Cell Death
  • Clinical Trials as Topic
  • Humans
  • Models, Biological
  • Protein Kinases / metabolism*
  • Reactive Oxygen Species / metabolism*
  • TOR Serine-Threonine Kinases


  • Reactive Oxygen Species
  • Protein Kinases
  • MTOR protein, human
  • TOR Serine-Threonine Kinases