Increased oxidative stress in patients with amyotrophic lateral sclerosis/Parkinsonism-dementia complex in the Kii peninsula, Japan

Mov Disord. 2009 Jan 15;24(1):123-6. doi: 10.1002/mds.22362.


Amyotrophic lateral sclerosis and Parkinsonism-dementia complex of the Kii peninsula (Kii ALS/PDC) is an endemic and a tauopathy, which shows clinical symptoms of amyotrophy, parkinsonism, and dementia. The objective of this study was to report the role of oxidative stress on Kii ALS/PDC using biochemical analysis. Urinary 8-hydroxydeoxyguanosine (8-OHdG)/creatinine ratio was analyzed in 11 patients with Kii ALS/PDC and 8 normal controls. The mean level of urinary 8-OHdG/creatinine ratio of the patients with Kii ALS/PDC was significantly higher than that of control subjects. Oxidative stress may be implicated in pathogenesis of Kii ALS/PDC.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Amyotrophic Lateral Sclerosis / epidemiology
  • Amyotrophic Lateral Sclerosis / metabolism*
  • Amyotrophic Lateral Sclerosis / urine
  • Creatinine / therapeutic use
  • Endemic Diseases
  • Female
  • Guanosine / analogs & derivatives
  • Guanosine / urine
  • Humans
  • Japan / epidemiology
  • Male
  • Oxidative Stress*
  • Parkinsonian Disorders / epidemiology
  • Parkinsonian Disorders / metabolism*
  • Parkinsonian Disorders / urine
  • Severity of Illness Index
  • Tauopathies / epidemiology
  • Tauopathies / metabolism*
  • Tauopathies / urine


  • Guanosine
  • 8-hydroxyguanosine
  • Creatinine