Postprandial plasma D-lactate concentrations after yogurt ingestion

Z Ernahrungswiss. 1991 Jun;30(2):131-7. doi: 10.1007/BF01610068.


The risk of D-lactic acidosis after consumption of yogurt was investigated in seven healthy volunteers. After ingestion of yogurt containing 1.06 mmol/kg body weight, D-lactic acid postprandial plasma D-lactate concentrations increased from 0.070 +/- 0.020 to a maximum of 0.200 +/- 0.010 mmol/l within 60 min. That was half the maximum concentration after the equivalent amount of D-lactate in the form of an aqueous solution of DL-lactate. The shape of the postprandial plasma D-lactate peak was flatter, but much broader after yogurt than after the aqueous solution, the peak areas being equal. When 0.64 mmol/kg body weight D-lactate were consumed as yogurt, plasma concentrations amounted to 0.086 +/- 0.030 mmol/l. Signs of a mild, transient, compensated metabolic acidosis, which was apparent in case of the aqueous lactic acid solution did not occur in case of yogurt. It is concluded that the consumption of foods containing D-lactic acid gives no reason for concern in healthy adults.

MeSH terms

  • Acidosis, Lactic / etiology*
  • Adult
  • Bicarbonates / blood
  • Female
  • Humans
  • Hydrogen-Ion Concentration
  • Lactates / adverse effects*
  • Lactates / blood*
  • Lactic Acid
  • Male
  • Middle Aged
  • Yogurt / adverse effects*


  • Bicarbonates
  • Lactates
  • Lactic Acid