Dexterous movement complexity and cerebellar activation: a meta-analysis

Brain Res Rev. 2009 Mar;59(2):316-23. doi: 10.1016/j.brainresrev.2008.09.003. Epub 2008 Oct 17.


The importance of the cerebellum in coordinates of movement has been established by lesion studies. However, there is no clear understanding of whether there is consistent activation in cerebellum across various motor task complexities or how different parts of the cerebellum contribute to finger coordinates in dexterous manipulation. This article reviews imaging studies with data from healthy subjects. A mini meta-analysis using label-based and activation likelihood estimation (ALE) methods reveals that ipsilateral anterior and vermis regions of the cerebellum were consistently activated across various dexterous movement complexities and were associated with finger and hand movement.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain Mapping / methods
  • Cerebellum / anatomy & histology*
  • Cerebellum / physiology*
  • Fingers / innervation
  • Fingers / physiology*
  • Functional Laterality / physiology
  • Humans
  • Motor Skills / physiology*
  • Movement / physiology*
  • Muscle, Skeletal / innervation
  • Muscle, Skeletal / physiology
  • Neurophysiology / methods