Prevalence of depression and its effect on disability in patients with age-related macular degeneration

Indian J Ophthalmol. Nov-Dec 2008;56(6):469-74. doi: 10.4103/0301-4738.42643.


Aims: To estimate depression in patients with age-related macular degeneration (AMD) and study the relationships among depression, visual acuity, and disability.

Materials and methods: It was a cross-sectional study with consecutive sampling (n = 53) of patients with AMD aged 50 years and above attending the retina clinic of a tertiary care hospital in North India. Depression, general disability and vision-specific disability were assessed in subjects meeting selection criteria. Assessments were done using the fourth edition of Diagnostic and Statistical Manual of mental disorders (DSM- IV) Geriatric Depression Scale (GDS), Structured Clinical Interview for DSM-IV Axis -I Disorders, Clinical Version (SCID-CV), World Health Organization Disability Assessment Schedule-II (WHODAS-II) and Daily Living Tasks dependent on Vision scale (DLTV). Non-parametric correlation analyses and regression analyses were performed.

Results: Out of 53 participants, 26.4% (n = 14) met DSM-IV criteria for the diagnosis of depressive disorder. Depressed patients had significantly greater levels of general and vision-specific disability than non-depressed patients. General disability was predicted better by depression and vision-specific disability than by visual acuity.

Conclusion: Depression is a major concern in patients with AMD and contributes more to disability than visual impairment.

MeSH terms

  • Aged
  • Cross-Sectional Studies
  • Depressive Disorder / epidemiology*
  • Depressive Disorder / etiology
  • Disability Evaluation*
  • Female
  • Humans
  • India / epidemiology
  • Macular Degeneration / complications
  • Macular Degeneration / epidemiology*
  • Male
  • Neuropsychological Tests
  • Prevalence
  • Vision Disorders / epidemiology*
  • Vision Disorders / etiology
  • Visual Acuity