Mindfulness predicts relapse/recurrence in major depressive disorder after mindfulness-based cognitive therapy

J Nerv Ment Dis. 2008 Aug;196(8):630-3. doi: 10.1097/NMD.0b013e31817d0546.


Empirical evidence for the effectiveness of mindfulness-based cognitive therapy (MBCT) is encouraging. However, data concerning the role of mindfulness in its relapse preventive effect are lacking. In our study, 25 formerly depressed patients received MBCT. Mindfulness was assessed before and immediately after MBCT using the Mindful Attention and Awareness Scale. Mindfulness significantly increased during MBCT, and posttreatment levels of mindfulness predicted the risk of relapse/recurrence to major depressive disorder in the 12-month follow-up period. Mindfulness predicted the risk of relapse/recurrence after controlling for numbers of previous episodes and residual depressive symptoms. The results provide preliminary evidence for the notion that mindfulness is an important factor in relapse prevention in major depression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Attention*
  • Awareness*
  • Cognitive Behavioral Therapy / methods*
  • Depressive Disorder, Major / diagnosis
  • Depressive Disorder, Major / therapy*
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Meditation
  • Middle Aged
  • Personality Inventory / statistics & numerical data
  • Psychometrics
  • Psychotherapy, Group / methods*
  • Risk Factors
  • Secondary Prevention
  • Thinking*
  • Treatment Outcome