Cardiac surgery in patients with haemophilia B: a case report and review of the literature

Haemophilia. 2009 Jan;15(1):108-13. doi: 10.1111/j.1365-2516.2008.01918.x. Epub 2008 Oct 23.


Cardiac surgery for coronary heart disease, and for calcific and degenerative valvular heart disease, will likely become more frequent with an ageing haemophilia population. Our report describes the successful management of an individual with mild haemophilia B undergoing elective aortic valve replacement using a continuous infusion of recombinant factor IX. Emphasis is placed on the multidisciplinary coordination of care required across three hospital sites to ensure an uncomplicated peri- and postoperative course. We also provide a review of the current literature on cardiac surgery in patients with haemophilia B.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aortic Valve / surgery*
  • Aortic Valve Stenosis / complications
  • Aortic Valve Stenosis / surgery*
  • Factor IX / administration & dosage
  • Factor IX / therapeutic use
  • Heart Valve Prosthesis Implantation*
  • Hemophilia B / complications
  • Hemophilia B / drug therapy*
  • Hemostasis, Surgical / methods
  • Humans
  • Infusions, Intravenous
  • Male
  • Middle Aged
  • Perioperative Care / methods
  • Recombinant Proteins / administration & dosage
  • Recombinant Proteins / therapeutic use


  • Recombinant Proteins
  • Factor IX