Comparison of low-dose human menopausal gonadotropin and micronized 17beta-estradiol supplementation in in vitro maturation cycles with thin endometrial lining

Fertil Steril. 2009 Sep;92(3):907-912. doi: 10.1016/j.fertnstert.2008.07.1750. Epub 2008 Oct 30.


Objective: A challenge of in vitro maturation (IVM) treatment in some women is insufficient development of the endometrium prior to embryo transfer.

Design: Retrospective study.

Setting: McGill Reproductive Center, Montreal, Canada.

Patient(s): Women with endometrial thickness <6 mm on days 6-10 ultrasound (US) scan of IVM treatment.

Intervention(s): In the human menopausal gonadotropin (hMG) group, 150 IU/day of hMG was started and in the estradiol group, 6 to 12 mg/day of micronized 17beta-estradiol was initiated. Additional US scans were performed 2 to 3 days apart, until endometrial thickness reached > or =8 mm or a dominant follicle (>10 mm) was identified.

Main outcome measure(s): Endometrial lining before oocyte retrival.

Result(s): In both groups endometrial lining significantly thickened following treatment. However, hMG treatment resulted in a higher number of follicles > or =7 mm compared to estradiol (7.4 +/- 4.8 vs. 3.4 +/- 2.5, respectively) and a significantly higher percentage of mature oocytes that were identified on the day of oocyte retrieval (in vivo matured oocytes) (15.1% vs. 10.5%).

Conclusion(s): In IVM designated cycles with a thin endometrium both low-dose hMG and micronized 17beta-estradiol supplementation significantly improve endometrial thickness. However, low-dose hMG results in larger follicles and a greater number of in vivo matured oocytes.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Cell Proliferation / drug effects
  • Dose-Response Relationship, Drug
  • Embryo Transfer / methods*
  • Endometrium / cytology
  • Endometrium / diagnostic imaging*
  • Endometrium / drug effects*
  • Estradiol / pharmacology*
  • Female
  • Fertility Agents, Female / pharmacology*
  • Fertilization in Vitro / methods
  • Humans
  • Menotropins / pharmacology*
  • Menstrual Cycle / drug effects*
  • Oocytes / cytology
  • Oocytes / drug effects
  • Ovarian Hyperstimulation Syndrome / epidemiology
  • Retrospective Studies
  • Risk Factors
  • Treatment Outcome
  • Ultrasonography


  • Fertility Agents, Female
  • Estradiol
  • Menotropins