Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones

Okram Mukherjee Singh; Sarangthem Joychandra Singh; Mutum Babita Devi; Laitonjam Nalini Devi; Nameirakpam Irabanta Singh; Sang-Gyeong Lee

doi:10.1016/j.bmcl.2008.10.063

Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones

Bioorg Med Chem Lett. 2008 Dec 15;18(24):6462-7. doi: 10.1016/j.bmcl.2008.10.063. Epub 2008 Oct 18.

Authors

Okram Mukherjee Singh¹, Sarangthem Joychandra Singh, Mutum Babita Devi, Laitonjam Nalini Devi, Nameirakpam Irabanta Singh, Sang-Gyeong Lee

Affiliation

¹ Department of Chemistry, Manipur University, Canchipur, Imphal 795003, Manipur, India. ok_mukherjee@yahoo.co.in

PMID: 18977139
DOI: 10.1016/j.bmcl.2008.10.063

Abstract

Copper (II) chloride in the absence of any solvent, efficiently catalyses the synthesis of dihydropyrimidinones (80-96% yields) by the Biginelli reaction. Six compounds were selected and examined their antifungal activities against the radial growth of three fungal species viz., Trichoderma hammatum, Trichoderma koningii and Aspergillus niger.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / chemical synthesis*
Antifungal Agents / pharmacology*
Aspergillus niger / metabolism
Catalysis
Chemistry, Pharmaceutical / methods
Copper / chemistry
Drug Design
In Vitro Techniques
Microbial Sensitivity Tests
Models, Chemical
Pyrimidinones / chemical synthesis
Pyrimidinones / pharmacology*
Solvents / chemistry
Time Factors
Trichoderma / metabolism

Substances

Antifungal Agents
Pyrimidinones
Solvents
Copper
cupric chloride