Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Dec;40(12):1404-6.
doi: 10.1038/ng.254. Epub 2008 Nov 2.

Lung Cancer Susceptibility Locus at 5p15.33

Affiliations
Free PMC article

Lung Cancer Susceptibility Locus at 5p15.33

James D McKay et al. Nat Genet. .
Free PMC article

Abstract

We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159 controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated disease markers at 5p15.33, rs402710 and rs2736100 were detected by the genome-wide data (P = 2 x 10(-7) and P = 4 x 10(-6)) and replicated by the independent study series (P = 7 x 10(-5) and P = 0.016). The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology.

Figures

Figure 1
Figure 1
Forest plot representing lung cancer risk and the two variants in the 5p region (rs402710 and rs2736100). Apart from the odds ratios for heterozygous and homozygous effect (*), odds ratios and 95% confidence intervals are derived from the per-allele model. All models are adjusted for age, sex and country. The overall OR is shown by the broken vertical line. P values are from heterogeneity tests.

Similar articles

See all similar articles

Cited by 290 articles

See all "Cited by" articles

Publication types

Feedback