Vitamin D and diabetes mellitus

Endocrine. 2009 Feb;35(1):11-7. doi: 10.1007/s12020-008-9115-5. Epub 2008 Nov 1.


Better understanding of the physiological role of the vitamin-D system, in particular its potential effects on inflammatory and autoimmune conditions as well as on insulin secretion and possibly also on insulin resistance, increased the interest in its potential role in prevention and control of the diabetic condition, both type-1 and -2 diabetes. Both these conditions are associated with inflammation and type-1 diabetes also with an autoimmune pathology. Indeed, animal and human studies support the notion that adequate vitamin-D supplementation may decrease the incidence of type-1 and possibly also of type-2 diabetes mellitus and may improve the metabolic control in the diabetes state. However, the exact mechanisms by which vitamin-D and calcium supplementation exert their beneficial effects are not clear and need further investigation.

Publication types

  • Review

MeSH terms

  • Animals
  • Diabetes Mellitus / etiology*
  • Diabetes Mellitus / immunology
  • Diabetes Mellitus / metabolism
  • Humans
  • Immune System / drug effects
  • Immune System / physiopathology
  • Inflammation / physiopathology
  • Insulin / metabolism
  • Insulin Resistance / physiology
  • Insulin Secretion
  • Vitamin D / metabolism
  • Vitamin D / pharmacology
  • Vitamin D / physiology*


  • Insulin
  • Vitamin D