[Testicular cancer - explanatory models for high cisplatin chemosensibility and new therapeutic options]

Aktuelle Urol. 2008 Nov;39(6):429-35. doi: 10.1055/s-2008-1038284. Epub 2008 Oct 31.
[Article in German]

Abstract

This article offers a review about the current facts of chemotherapy in testicular cancer. Besides a short presentation of the guideline-standard therapy the authors deal with the question as to why testicular cancer shows an extraordinarily high chemosensibility compared to other tumours. Furthermore, the current data on alternative chemotherapies as well as of molecular, molecular-genetic and pharmacogenetic therapeutic concepts are explored. Data were obtained from researches in Medline of the Pubmed database.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / pharmacokinetics
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Apoptosis / drug effects*
  • Cell Line, Tumor
  • Cisplatin / administration & dosage*
  • Cisplatin / pharmacokinetics
  • Cysteine Endopeptidases / genetics
  • DNA Repair / drug effects
  • DNA Repair / genetics
  • DNA-Binding Proteins / genetics
  • Dose-Response Relationship, Drug
  • Drug Resistance, Neoplasm / genetics
  • Endonucleases / genetics
  • Humans
  • Male
  • Neoplasm Staging
  • Neoplasms, Germ Cell and Embryonal / drug therapy*
  • Neoplasms, Germ Cell and Embryonal / genetics
  • Neoplasms, Germ Cell and Embryonal / mortality
  • Neoplasms, Germ Cell and Embryonal / pathology
  • Polymorphism, Genetic / genetics
  • Practice Guidelines as Topic
  • Survival Rate
  • Testicular Neoplasms / drug therapy*
  • Testicular Neoplasms / genetics
  • Testicular Neoplasms / mortality
  • Testicular Neoplasms / pathology
  • Tumor Suppressor Protein p53 / genetics

Substances

  • DNA-Binding Proteins
  • Tumor Suppressor Protein p53
  • ERCC1 protein, human
  • Endonucleases
  • Cysteine Endopeptidases
  • bleomycin hydrolase
  • Cisplatin