Beyond licensing and disarming: a quantitative view on NK-cell education

Eur J Immunol. 2008 Nov;38(11):2934-7. doi: 10.1002/eji.200838760.


In this article, we will move beyond the current controversy of different models for NK-cell education and instead discuss the properties characterizing MHC class I-guided functional development of NK cells. We will argue that this development, which represents the endpoint of NK-cell education, is a quantitative and dynamic, and perhaps even reversible, process.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Histocompatibility Antigens Class I / physiology
  • Humans
  • Immune Tolerance
  • Killer Cells, Natural / immunology*
  • Models, Immunological


  • Histocompatibility Antigens Class I