Interrelationships between B-type natriuretic peptides and vitamin D in patients on maintenance peritoneal dialysis

Perit Dial Int. Nov-Dec 2008;28(6):617-21.

Abstract

Objective: Experimental evidence suggests that vitamin D deficiency impairs cardiac structure and function. Our objective was to observe relationships between circulating levels of the cardiac natriuretic peptides and vitamin D levels in patients on chronic peritoneal dialysis.

Method: Measurements were made of circulating levels of 25-hydroxyvitamin D [25(OH)D] and plasma B-type natriuretic peptide (BNP) levels in patients receiving chronic peritoneal dialysis.

Results: Both BNP and the 1-76 amino-terminal fragment of pro-BNP correlated inversely with 25(OH)D levels (rs = -0.60, p = 0.007, and rs = -0.64, p = 0.003, respectively) in patients on peritoneal dialysis.

Conclusions: Vitamin D deficiency in chronic renal failure may impair cardiac function, as manifested by elevated levels of B-type cardiac natriuretic peptides.

MeSH terms

  • Adult
  • Aged
  • Creatinine / blood
  • Female
  • Humans
  • Male
  • Middle Aged
  • Natriuretic Peptide, Brain / blood*
  • Parathyroid Hormone / blood
  • Peptide Fragments / blood
  • Peritoneal Dialysis*
  • Vitamin D / analogs & derivatives*
  • Vitamin D / blood

Substances

  • Parathyroid Hormone
  • Peptide Fragments
  • pro-brain natriuretic peptide (1-76)
  • Natriuretic Peptide, Brain
  • Vitamin D
  • 25-hydroxyvitamin D
  • Creatinine