Studies on the synthesis andin vitro anti-tumor activity of dihydroberberine derivatives

Arch Pharm Res. 1997 Oct;20(5):476-9. doi: 10.1007/BF02973943.

Abstract

Three types of dihydroberberine derivatives such as spirobenzylisoquinoline, benzindenoazepine and cyclopropanated quinolizine species were synthesized from dihydroberberine for the investigation on their anti-tumor activity. Among them, cyclopropanated quinolizine species were more effective than spirobenzylisoquinoline and benzindenoazepine against P-388 and L-1210 leukemia cell.