NFIX--one gene, two knockouts, multiple effects

J Biol. 2008 Oct 23;7(8):29. doi: 10.1186/jbiol94.


A previous knockout of the transcription factor gene nuclear factor IX (NFIX) in mice produced impaired development of the corpus callosum and severe skeletal defects. A recent paper in BMC Developmental Biology reports an apparently similar NFIX knockout that produced marked differences in phenotype, raising intriguing general questions about the possible causes of such differences in mouse knockouts.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Agenesis of Corpus Callosum*
  • Animals
  • Bone and Bones / abnormalities*
  • Gene Silencing*
  • Hydrocephalus / genetics
  • Mice
  • Mice, Knockout
  • NFI Transcription Factors / genetics*
  • Osteogenesis


  • NFI Transcription Factors
  • Nfix protein, mouse