Large-scale assignment of orthology: back to phylogenetics?

Genome Biol. 2008 Oct 30;9(10):235. doi: 10.1186/gb-2008-9-10-235.


Reliable orthology prediction is central to comparative genomics. Although orthology is defined by phylogenetic criteria, most automated prediction methods are based on pairwise sequence comparisons. Recently, automated phylogeny-based orthology prediction has emerged as a feasible alternative for genome-wide studies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Databases, Genetic
  • Genome
  • Genomics / methods*
  • Models, Genetic
  • Phylogeny*
  • Sequence Alignment / methods