Protein and DNA-sequence homologies between the V3-loop of human immunodeficiency virus type I envelope protein gp120 and immunoglobulin variable regions

Biochem Biophys Res Commun. 1991 Sep 16;179(2):1056-62. doi: 10.1016/0006-291x(91)91926-4.


We found that a common amino acid sequence motif exists between the V3-loop region of the human immunodeficiency virus type I envelope protein HIV gp120 and the human immunoglobulin heavy chain variable regions of subclass III (Ig VH-III). In the Ig VH-III sequences, the common motif overlaps with framework-1, complementarity-determining-region-1 and framework-2. In the homologous regions, the two groups of sequences also have a similar distribution of residue variability. On the DNA sequence level, the homology includes the conserved rearrangement signals of the VH-III genes, which lends support to the speculation that the V3 region of gp120 also may be involved in rearrangement processes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Consensus Sequence
  • DNA, Viral / genetics*
  • Genes, Immunoglobulin / genetics*
  • Genetic Variation
  • HIV Envelope Protein gp120 / genetics*
  • HIV-1 / genetics*
  • Molecular Sequence Data
  • Sequence Alignment
  • Sequence Homology, Nucleic Acid


  • DNA, Viral
  • HIV Envelope Protein gp120