Autism: many genes, common pathways?

Cell. 2008 Oct 31;135(3):391-5. doi: 10.1016/j.cell.2008.10.016.


Autism is a heterogeneous neurodevelopmental syndrome with a complex genetic etiology. It is still not clear whether autism comprises a vast collection of different disorders akin to intellectual disability or a few disorders sharing common aberrant pathways. Unifying principles among cases of autism are likely to be at the level of brain circuitry in addition to molecular pathways.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autistic Disorder / genetics*
  • Autistic Disorder / metabolism*
  • Genetic Variation
  • Humans
  • Mutation
  • Signal Transduction*