The autistic neuron: troubled translation?

Cell. 2008 Oct 31;135(3):401-6. doi: 10.1016/j.cell.2008.10.017.


Autism is a complex genetic disorder, but single-gene disorders with a high prevalence of autism offer insight into its pathogenesis. Recent evidence suggests that some molecular defects in autism may interfere with the mechanisms of synaptic protein synthesis. We propose that aberrant synaptic protein synthesis may represent one possible pathway leading to autistic phenotypes, including cognitive impairment and savant abilities.

MeSH terms

  • Animals
  • Autistic Disorder / metabolism*
  • Cognition
  • Humans
  • Mice
  • Nerve Tissue Proteins / metabolism*
  • Neuronal Plasticity
  • Neurons / metabolism*
  • Protein Biosynthesis*
  • Synapses / metabolism


  • Nerve Tissue Proteins