The self-tuning neuron: synaptic scaling of excitatory synapses

Cell. 2008 Oct 31;135(3):422-35. doi: 10.1016/j.cell.2008.10.008.


Homeostatic synaptic scaling is a form of synaptic plasticity that adjusts the strength of all of a neuron's excitatory synapses up or down to stabilize firing. Current evidence suggests that neurons detect changes in their own firing rates through a set of calcium-dependent sensors that then regulate receptor trafficking to increase or decrease the accumulation of glutamate receptors at synaptic sites. Additional mechanisms may allow local or network-wide changes in activity to be sensed through parallel pathways, generating a nested set of homeostatic mechanisms that operate over different temporal and spatial scales.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Brain / physiology*
  • Homeostasis
  • Humans
  • Neuronal Plasticity*
  • Neurons / physiology*
  • Synapses / physiology