Antiarthritic effects of glucosamine sulfate studied in animal models

Arzneimittelforschung. 1991 May;41(5):542-5.

Abstract

The antireactive activity of glucosamine sulfate (GS) (CAS 29031-19-4) was tested in the rat in experimental models of subacute inflammation (sponge granuloma and croton oil granuloma), on subacute mechanical arthritis (kaolin arthritis) and in immunological-reactive arthritis and generalized inflammation (adjuvant arthritis). On these models GS was found effective in oral daily doses of 50-800 mg/kg. Tne potency of GS in comparison of that of indometacin used in the same tests as reference substance was found 50-300 times lower. Since, however, the toxicity of indometacin in chronic toxicity experiments is 1000-4000 times larger, the therapeutic margin with regard to prolonged treatments of inflammatory disorders results 10-30 times more favourable for GS than for indometacin. GS can therefore be considered as a drug of choice for prolonged oral treatment of rheumatic disorders.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal
  • Arthritis / chemically induced
  • Arthritis / drug therapy*
  • Arthritis, Experimental / drug therapy
  • Croton Oil
  • Glucosamine / adverse effects
  • Glucosamine / pharmacology*
  • Granuloma / chemically induced
  • Granuloma / drug therapy
  • Indomethacin / pharmacology
  • Joints / drug effects
  • Kaolin
  • Male
  • Rats
  • Rats, Inbred Strains

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Kaolin
  • Croton Oil
  • Glucosamine
  • Indomethacin