[Elevation of PSA after prostate radiotherapy: rebound or biochemical recurrence?]

Prog Urol. 2008 Oct;18(9):557-61. doi: 10.1016/j.purol.2008.06.001. Epub 2008 Jul 26.
[Article in French]

Abstract

The fact that external beam radiotherapy and brachytherapy are now considered to be curative techniques has led to major review of the modalities of follow-up after radiotherapy for prostate cancer. The problem concerns both the diagnosis of recurrence, rapidly announced by elevation of prostatic-specific antigen (PSA), usually at a subclinical stage, and the validity of criteria of biochemical recurrence to allow comparison of various study. Physicians involved in follow-up should be aware of the potential of bounce in PSA follow-up after external beam radiotherapy or brachytherapy. The PSA bounce phenomemon was defined by a rise of PSA values (+0.1 -0.8 ng/ml) with a subsequent fall. Biochemical failure after external beam radiotherapy or brachytherapy (with or without hormonotherapy) was defined by Phoenix criteria by a rise of 2 ng/ml above an initial PSA nadir. This definition was more correlated to PSA bounce phenomenon.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Diagnosis, Differential
  • Humans
  • Male
  • Neoplasm Recurrence, Local / blood*
  • Neoplasm Recurrence, Local / diagnosis
  • Prostate-Specific Antigen / blood*
  • Prostatic Neoplasms / blood*
  • Prostatic Neoplasms / diagnosis
  • Prostatic Neoplasms / radiotherapy*

Substances

  • Prostate-Specific Antigen