5-Lipoxygenase: mechanisms of regulation

J Lipid Res. 2009 Apr;50 Suppl(Suppl):S40-5. doi: 10.1194/jlr.R800062-JLR200. Epub 2008 Nov 5.


5-lipoxygenase (5-LO) catalyzes two steps in biosynthesis of leukotrienes (LTs), a group of lipid mediators of inflammation derived from arachidonic acid (AA). LT antagonists are used in treatment of asthma; more recently a potential role also in atherosclerosis has raised considerable interest. Furthermore, possible effects of 5-LO metabolites in relation to tumorigenesis have emerged. Thus, an understanding of the biochemistry of this lipoxygenase has potential implications for treatment of various diseases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arachidonate 5-Lipoxygenase / chemistry
  • Arachidonate 5-Lipoxygenase / genetics
  • Arachidonate 5-Lipoxygenase / metabolism*
  • Calcitriol / pharmacology
  • Enzyme Activation
  • Gene Expression Regulation, Enzymologic / drug effects
  • Humans
  • Neutrophils / enzymology
  • Transforming Growth Factor beta / pharmacology


  • Transforming Growth Factor beta
  • Arachidonate 5-Lipoxygenase
  • Calcitriol