Metastasis and AKT activation

J Cell Physiol. 2009 Mar;218(3):451-4. doi: 10.1002/jcp.21616.


Metastasis, responsible for 90% of cancer patient deaths, is an inefficient process because many tumor cells die. The survival of metastatic tumor cells should be considered as a critical therapeutic target. This review provides a new perspective regarding the role of AKT in tumor survival, and the rationale to target AKT in anti-metastasis therapies.

Publication types

  • Review

MeSH terms

  • Enzyme Activation
  • Humans
  • Neoplasm Metastasis / pathology*
  • Proto-Oncogene Proteins c-akt / metabolism*


  • Proto-Oncogene Proteins c-akt