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Abstract

Genetic contribution to the development of attention deficit hyperactivity disorder (ADHD) is well established. Seven independent genome-wide linkage scans have been performed to map loci that increase the risk for ADHD. Although significant linkage signals were identified in some of the studies, there has been limited replications between the various independent datasets. The current study gathered the results from all seven of the ADHD linkage scans and performed a Genome Scan Meta Analysis (GSMA) to identify the genomic region with most consistent linkage evidence across the studies. Genome-wide significant linkage (P(SR) = 0.00034, P(OR) = 0.04) was identified on chromosome 16 between 64 and 83 Mb. In addition there are nine other genomic regions from the GSMA showing nominal or suggestive evidence of linkage. All these linkage results may be informative and focus the search for novel ADHD susceptibility genes.

Figures

Fig. 1
Fig. 1
Weighted (red) and unweighted (blue) −log10(PSR) from GSMA analysis of the 7 ADHD linkage scans. The thresholds of nominal (P=0.05) suggestive (P=0.0083) and genome-wide significant linkage (P=0.000417 after Bonferroni correction) are shown.
Fig. 2
Fig. 2
Individual linkage scan results for chromosome 16q (bins 16.3–16.4) from 6 studies.

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